Arbitrage Bots vs Gas Fees

I’m interested in building an arbitrage bot for token swapping. But I understand that prices on, say, uniSwap are rather high. Can anyone comment on how one would work around this challenge? I thought that to take advantage of arbitrage, you are looking for slight differences in prices, but if you add in some gas to the equation, you’re looking at a significant diff in price, which seems to defeat the purpose of arbitrage. Can anyone comment on this?